Vitamin D3
Also known as: cholecalciferol, colecalciferol
Classification
Unknown
Regulatory Status
dietary supplement / OTC vitamin; some high-strength products dispensed as prescription
Sources
3
Review
n/a
Overview
Vitamin D3 (cholecalciferol) is converted to 25-hydroxyvitamin D and then to active 1,25-dihydroxyvitamin D, which binds the vitamin D receptor to promote intestinal calcium absorption and support bone mineral homeostasis.
Evidence and limitations
Human/preclinical evidence breakdown is not available in this record.
Pathways
Benefits
NIH ODS describes vitamin D as essential for calcium absorption and bone health; large trials have not shown routine supplementation prevents major CV events or cancer in generally healthy adults.
Interactions & cautions
Flagged in source data
Drug interactions
thiazide diuretics — Increased hypercalcemia risk when combined with high-dose vitamin D (review)
other vitamin D analogs or high-dose calcium — Increased toxicity risk (review)
These are observational flags for review, not individualized instructions.
Sources
Educational reference only — not medical advice.
What people report (anecdote)
CLINICAL DATA (from trials)
Adverse events:
None recorded in our sources.
Effects measured:
Human trials: none found.
ANECDOTE
What people report: anecdote, not evidence
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