Sermorelin
Also known as: GRF 1-29, GHRH(1-29)NH2, Sermorelin acetate, Somatorelin (related INN), Geref
Classification
Peptide
Regulatory Status
not-established
Sources
11
Review
n/a
Overview
Sermorelin (acetate) is a synthetic 29-amino-acid peptide corresponding to the amino-terminal, biologically active segment of native human growth hormone-releasing hormone (GHRH); it acts as a GHRH-receptor agonist on the anterior pituitary to stimulate endogenous growth hormone secretion.
Evidence and limitations
Human/preclinical evidence breakdown is not available in this record.
Pathways
Sermorelin (acetate) is a synthetic 29-amino-acid peptide corresponding to the amino-terminal, biologically active segment of native human growth hormone-releasing hormone (GHRH); it acts as a GHRH-receptor agonist on the anterior pituitary to stimulate endogenous growth hormone secretion.
Interactions & cautions
Drug interactions
somatropin, GHRPs, or other GH secretagogues — Additive GH-axis effects and monitoring burden may occur. (review)
These are observational flags for review, not individualized instructions.
Sources
- https://www.federalregister.gov/documents/2013/03/04/2013-04827/determination-that-geref-sermorelin-acetate-injection-05-milligrams-basevial-and-10-milligrams (opens in a new tab)
- https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=sermorelin (opens in a new tab)
- https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks (opens in a new tab)
Educational reference only — not medical advice.
What people report (anecdote)
CLINICAL DATA (from trials)
Adverse events:
None recorded in our sources.
Effects measured:
Human trials: none found.
ANECDOTE
What people report: anecdote, not evidence
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