MOTS-c
Also known as: mitochondrial-derived peptide, MOTS-c acetate, Mitochondrial Open Reading Frame of the 12S rRNA-c
Classification
Peptide
Regulatory Status
not-established
Overview
MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA (within the 12S rRNA region) that acts via AMPK-dependent signaling; in mice it regulates skeletal-muscle metabolism and nuclear genes related to metabolism and proteostasis, and endogenous MOTS-c is exercise-inducible, rising in circulation during and after acute exercise in humans.
Evidence and limitations
Human/preclinical evidence breakdown is not available in this record.
Pathways
MOTS-c is a 16-amino-acid peptide encoded within mitochondrial DNA (within the 12S rRNA region) that acts via AMPK-dependent signaling; in mice it regulates skeletal-muscle metabolism and nuclear genes related to metabolism and proteostasis, and endogenous MOTS-c is exercise-inducible, rising in circulation during and after acute exercise in humans.
Interactions & cautions
Drug interactions
other AMPK-pathway or metabolic peptides — No specific interaction table established; class risk of unknown peptide co-administration applies. (review)
These are observational flags for review, not individualized instructions.
Sources
Educational reference only — not medical advice.