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L-citrulline

Also known as: citrulline

Classification

Unknown

Regulatory Status

n/a

Sources

2

Review

n/a

Overview

L-citrulline is a non-proteinogenic amino acid that increases de novo arginine availability and supports nitric-oxide-related vasodilation pathways; it is commonly marketed in sports nutrition.

Evidence and limitations

Human/preclinical evidence breakdown is not available in this record.

Pathways

nitric-oxide-pathwayurea-cyclenitric oxide precursorvasodilation

Benefits

People look up L-citrulline for pump/blood-flow and exercise performance support via arginine/NO pathways; it is a supplement ingredient, not an FDA-approved drug for these uses.

Interactions & cautions

PDE5 inhibitors without review

nitrates or PDE5 inhibitors — Potential additive or opposing effects may occur. (review)

nitrates or PDE5 inhibitors — Potential additive blood-pressure-lowering effects (review)

These are observational flags for review, not individualized instructions.

Sources

Educational reference only — not medical advice.

What people report (anecdote)

CLINICAL DATA (from trials)

Adverse events:

None recorded in our sources.

Effects measured:

Human trials: none found.

ANECDOTE

What people report: anecdote, not evidence

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L-citrulline: what the evidence actually says | BioStack