Clomiphene
Also known as: Clomid, clomiphene citrate, Clomifene, Serophene
Classification
Serm
Regulatory Status
FDA-approved prescription product
Sources
2
Review
n/a
Overview
Clomiphene citrate is a SERM that antagonizes estrogen feedback at the hypothalamus/pituitary, increasing gonadotropin (FSH/LH) release and supporting ovulation in eligible women.
Evidence and limitations
Human/preclinical evidence breakdown is not available in this record.
Pathways
estrogen receptors (hypothalamus/pituitary)
Benefits
FDA-labeled use is treatment of ovulatory dysfunction in women who want pregnancy, under clinician supervision with full prescribing information.
Systematic review/meta-analysis of RCTs reports testosterone increases with clomiphene/enclomiphene in male hypogonadism contexts. This is not an FDA-approved indication and is not a recommendation.
Interactions & cautions
Flagged in source data
Drug interactions
exogenous gonadotropin therapies — Combined use can increase OHSS and multiple-pregnancy risk. (review)
These are observational flags for review, not individualized instructions.
Sources
Educational reference only — not medical advice.
What people report (anecdote)
CLINICAL DATA (from trials)
Adverse events:
None recorded in our sources.
Effects measured:
Human trials: none found.
ANECDOTE
What people report: anecdote, not evidence
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