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Survodutide

Also known as: BI 456906, BI-456906

Classification

Peptide

Regulatory Status

Overview

Survodutide (BI 456906) is an investigational dual agonist of the glucagon receptor and GLP-1 receptor studied for obesity and MASH with fibrosis.

Evidence and limitations

Human/preclinical evidence breakdown is not available in this record.

ClassB source cannot establish canonical regulatory or safety fields. The statements below are retained as uncertainty, not as a label-backed verdict. | Regulatory status: not-established | Contraindication: No approved US label; investigational dual agonist is not an authorized consumer product | Warning: Clinical trials report frequent gastrointestinal adverse events and higher discontinuation versus placebo | Adverse effect: nausea | Adverse effect: diarrhea | Adverse effect: vomiting | Adverse effect: other gastrointestinal events in trials | Serious adverse effect: full serious-risk profile not established in an approved US label; treatment discontinuations due to adverse events were substantially higher than placebo in trials

Pathways

incretin-signalingenergy-expenditurehepatic-lipid-metabolismglucagon receptor agonismGLP-1 receptor agonismGCGRGLP-1R

Interactions & cautions

other GLP-1 or dual/triple incretin agonists — Additive GI and metabolic effects may occur. (review)

These are observational flags for review, not individualized instructions.

Sources

Educational reference only — not medical advice.