St John's wort
Also known as: Hypericum perforatum
Classification
Supplement
Regulatory Status
Overview
St John's wort is a botanical discussed for depressive symptoms and is a known inducer of drug-metabolizing pathways. This record does not establish a treatment plan.
Evidence and limitations
Human/preclinical evidence breakdown is not available in this record.
ClassB source cannot establish canonical regulatory or safety fields. The statements below are retained as uncertainty, not as a label-backed verdict. | Regulatory status: not-established | Warning: Serious drug interactions from enzyme induction are the principal harm | Precaution: Risk profile is not a personal clearance | Adverse effect: gastrointestinal upset | Adverse effect: photosensitivity | Serious adverse effect: loss of effect of interacting medicines | Serious adverse effect: serotonin syndrome with serotonergic drugs
Pathways
Benefits
A PubMed systematic review examined St John's wort for major depressive disorder.
Interactions & cautions
Flagged in source data
These are observational flags for review, not individualized instructions.
Sources
Educational reference only — not medical advice.