Semax

Also known as: ACTH(4-7)-PGP, Met-Glu-His-Phe-Pro-Gly-Pro

Limited Evidence

Classification

Peptide

Regulatory Status

not-established

Overview

Semax is a synthetic heptapeptide analog related to ACTH(4-10); proposed mechanisms include melanocortin-pathway interaction or enkephalinase effects, but a definitive human pharmacological mechanism is not established by FDA labeling.

Evidence and limitations

Human/preclinical evidence breakdown is not available in this record.

Pathways

melanocortin-related-proposedneuroprotection-discussednot-established

ACTH-fragment peptide signaling (proposed)

Interactions & cautions

Drug interactions

other CNS-active nootropics or stimulants — Confounded cognitive or safety monitoring possible. (review)

These are observational flags for review, not individualized instructions.

Sources

https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks (opens in a new tab)
https://pubchem.ncbi.nlm.nih.gov/compound/Semax (opens in a new tab)
https://www.caymanchem.com/product/27719/semax (opens in a new tab)

Educational reference only — not medical advice.