SAMe
Also known as: S-adenosylmethionine, ademetionine
Classification
Supplement
Regulatory Status
Overview
SAMe is a methyl donor in one-carbon metabolism. A mood benefit is not established as a recommendation.
Evidence and limitations
Human/preclinical evidence breakdown is not available in this record.
ClassB source cannot establish canonical regulatory or safety fields. The statements below are retained as uncertainty, not as a label-backed verdict. | Regulatory status: not-established | Warning: Mania and serotonergic adverse effects are discussed risks | Precaution: Risk profile is not a personal clearance | Adverse effect: gastrointestinal upset | Serious adverse effect: mania is a discussed risk and a rate is not established
Pathways
Benefits
A PubMed systematic review examined SAMe for central nervous system health. This is not a use recommendation.
Interactions & cautions
Flagged in source data
These are observational flags for review, not individualized instructions.
Sources
Educational reference only — not medical advice.