Kisspeptin-10
Also known as: KP-10, Metastin(45-54), Kisspeptin 10 (human)
Classification
Peptide
Regulatory Status
not-established
Overview
Kisspeptin-10 is the minimal bioactive C-terminal decapeptide fragment of the KISS1 gene product (kisspeptin/metastin) and acts as an agonist at the KISS1R (GPR54) receptor, the key upstream activator of hypothalamic GnRH neurons in the hypothalamic-pituitary-gonadal (HPG) axis.
Evidence and limitations
Human/preclinical evidence breakdown is not available in this record.
Pathways
Kisspeptin-10 is the minimal bioactive C-terminal decapeptide fragment of the KISS1 gene product (kisspeptin/metastin) and acts as an agonist at the KISS1R (GPR54) receptor, the key upstream activator of hypothalamic GnRH neurons in the hypothalamic-pituitary-gonadal (HPG) axis.
Interactions & cautions
Drug interactions
GnRH analogues, gonadotropins, or other fertility hormones — Unpredictable LH/FSH and sex-steroid responses (review)
These are observational flags for review, not individualized instructions.
Sources
Educational reference only — not medical advice.