IGF-1 LR3
Also known as: Long R3 IGF-I, Long R3 IGF-1, Long-(Arg3)-IGF-I, LR3IGF-I, LongR3-IGF-I
Classification
Peptide
Regulatory Status
not-established
Overview
IGF-1 LR3 (Long-Arg3-IGF-I) is a synthetic 83-amino-acid analogue of human IGF-1 bearing an arginine substitution at position 3 and a 13-amino-acid N-terminal extension; these modifications reduce its affinity for IGF-binding proteins, contributing to a longer functional half-life and greater potency than native IGF-1 in preclinical models. FDA's Substance Registration System assigns it UNII M9L22Y19H9 with CAS 143045-27-6; commercial vendor chemical listings commonly cite a different CAS number (946870-92-4) for the same substance name, an identifier discrepancy that is unresolved.
Evidence and limitations
Human/preclinical evidence breakdown is not available in this record.
Pathways
IGF-1 LR3 (Long-Arg3-IGF-I) is a synthetic 83-amino-acid analogue of human IGF-1 bearing an arginine substitution at position 3 and a 13-amino-acid N-terminal extension; these modifications reduce its affinity for IGF-binding proteins, contributing to a longer functional half-life and greater potency than native IGF-1 in preclinical models. FDA's Substance Registration System assigns it UNII M9L22Y19H9 with CAS 143045-27-6; commercial vendor chemical listings commonly cite a different CAS number (946870-92-4) for the same substance name, an identifier discrepancy that is unresolved.
Interactions & cautions
Drug interactions
insulin or other hypoglycemic agents — Potential additive hypoglycemia risk (review)
These are observational flags for review, not individualized instructions.
Sources
- https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a8b27a1b-a611-4f91-ad22-76d4b390c3ae (opens in a new tab)
- https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-risks (opens in a new tab)
- https://precision.fda.gov/uniisearch/srs/unii/M9L22Y19H9 (opens in a new tab)
Educational reference only — not medical advice.